Seborrheic keratoses (senile keratosis) seborrheic keratosis or senile keratosis, keratosis warty benign tumor is most common in older people. They have a variety of clinical presentations and develop by proliferation of epidermal cells. Although not yet identified specific etiologic factors, they appear mostly on sun-exposed areas.
They are usually asymptomatic, but may be itchy, or you can hang clothes and become inflamed. Patients are worried about their malignancy. It begins with the emergence of well-defined macules, brown, flat. Lesions may be numerous or dispersed. As they grow develop a warty surface with many fine prominent follicles. They can grow, cause itching or bleeding. Seborrheic keratosis is benign and does not represent a danger to human health. The lesions usually do not resolve and grow and become hard with time.
Successful medical treatment presents the use of trichloroacetic acid, ammonium lactate or other chemical substances peeling damage. Teraapia surgery include cryotherapy with liquid nitrogen or carbon dioxide, and ciuretajul electrodesicarea, tangential biopsy, laser and dermoabraziunea.
Pathophysiology of Seborrheic Keratoses
Etiology of seborrheic keratosis development is not known. This presents obvious histological proliferation. Increased cell replication was demonstrated in seborrheic keratoses. Cross-linked lesions are seen on sun-exposed areas and can develop from lesions of lentigo. Seborrheic keratosis shows a variable degree of pigmentation. In pigmented seborrheic keratosis keratinocyte proliferation triggers activation of neighboring melanocytes.
The cause is not known sebereice keratosis. Some cases are inherited autosomal dominant. Sunlight seems to play a role in the development of seborrheic keratoses. Records show that some of the lesions have a clonal nature. Activating mutations in the gene encoding receptor tyrosine kinase is described in 85% of adenoid seborrheic keratoses.
Signs and symptoms in Seborrheic Keratoses
Seborrheic keratoses are the most common benign tumors occurring in older people. They seem to increase with age. Are described and young people. They are usually asymptomatic. Lesions may be pruritic, can cling to clothes and become inflamed. Are unattractive and present negative psychological connotations patient reminding him of his old age.
Patients are often concerned about malignizarii lesions. A person may have multiple lesions and may not notice a dysplastic nevus or a melanoma that develops between keratoses. A significant danger occurs when a person does not deteteaza its early stages malignant melanoma in.
Lesser-ral sign of multiple lesions is asociaerea keratozxa seborrheic rash with internal malignancy. The most common sign is seen in adenocarcinoma, especially of the gastrointestinal tract, however, a rash of seborrheic keratoses can occur after any inflammatory dermatosis (eczema, severe sunburn).
Keratoses sebereica inital form of patches appears flat, brown, well defined. Lesions may be numerous or dispersed. As they grow develop a warty surface followed by the appearance of numerous prominent follicles. They typically look the follicle introduced into the lesion. Lesion color may vary from light brown with pink tones up to dark brown and black. Include natural evolution and broadening slowly with increasing induration gradual development of new lesions.
There is a way of transmitting hereditary family injury in almost half of patients with autosomal dominant mechanism.